Read More
The Basanti Devi Amir Chand Prize is the earliest instituted award of ICMR,
founded in 1953 by late Major General Amir Chand for the significant research
contributions made by scientists in the field of biomedical sciences. This prize is
awarded to a research scientist engaged in any area of biomedical sciences.
The award for the year 2012 is being presented to Dr Debabrata Dash, Professor
& Head, Department of Biochemistry, Institute of Medical Sciences, Banaras Hindu
University, Varanasi for the research work on 'Elucidation of novel antithrombotic
applications of nanomaterials and pharmacological agents'.
The main focus of research of Prof. Dash has been (i) molecular basis of
platelet activation leading to prothrombotic pathologies, and (ii) interaction of
nanomaterials with blood platelets and thrombi having translational potential. He
has made studies on platelet biology, which include mechanisms of platelet ageing
and apoptosis, late signaling events underlying pathological thrombus formation
during stroke/coronary blockage, and unique anti-platelet effects of agents like
tamoxifen, propranolol, melatonin and crinumin. What limits platelet life span
to 10-12 days? With a series of incisive studies he has identified the molecular
regulators of platelet ageing, which can have therapeutic implications in conditions
like thrombocytopenia. In a platelet model he has identified the factor responsible
for amyloid-beta toxicity that can be a potential anti-Alzheimer drug target. His
design of an impedance-based graphene-coated biosensor for identification of
individuals with high thrombotic risk sparks innovation and is a great step toward
early diagnosis and prevention of coronary artery disorders. Prof. Dash has also
made significant contributions in understanding thrombo-compatibility of a series
of nanomaterials that include graphene, nanodiamond, nanosilver and nanogold.
He reported thrombogenic potential of graphene oxide and nanodiamond and
designed amine-modified graphene, which is safe for biomedical applications.
Prof. Dash has been awarded with Tata Innovation Fellowship by the Department
of Biotechnology, Ministry of Science & Technology, Government of India. He is a
Fellow of the Indian National Science Academy, New Delhi, the Indian Academy of
Sciences, Bengaluru and the National Academy of Medical Sciences, New Delhi. Dr
Dash has published 64 papers in various journals.